Force induced unfolding of proteins
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چکیده
Native structures of wild-type proteins may unfold as external conditions change. Usually unfolding occurs as a result of raising temperature, increasing the concentration of denaturants such as urea or guanidinium chloride, or changing pH. Only recently it has been recognized that certain wild-type proteins are subject to external force and in the course of performing biological functions they may unravel to adopt highly extended, stretched conformations.
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